The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients. It is designed as an observational cohort study with the retrospective and prospective longitudinal arms.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• acute (symptom onset to admission \<1 days) ischemic stroke
• ischemic stroke affecting the branches of anterior cerebral artery, middle cerebral artery and posterior cerebral artery
• age 18-80 years
• moderate or severe stroke (National Institutes of Health Stroke Scale, NIHSS\>=5)
• intravascular stroke treatment with thrombolysis or thrombectomy leading to satisfactory reperfusion (if applicable)
• informed consent
Locations
Other Locations
Russian Federation
Almazov National Medical Research Centre
RECRUITING
Saint Petersburg
Contact Information
Primary
Lyudmila Korostovtseva, MD, PHD
lyudmila_korosto@mail.ru
+79217873548
Time Frame
Start Date: 2018-05-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 250
Treatments
Retrospective cohort
Patients with acute ischemic stroke admitted to the Stroke Unit of one participating center in 2018-2022. The data collected within clinical routine will be analyzed including stroke characteristics at baseline and at discharge (10-14 days after admission), neuroimaging data, sleep characteristics (routine polygraphy study), heart rate variability, routine blood tests.
Prospective cohort
Approximately 200-250 patients with acute ischemic stroke admitted to the Stroke Unit of one participating center in 2022-2024 will undergo the assessment of medical records, stroke characteristics, the assessment of sleep characteristics and blood sampling for the evaluation of genetic biomarkers of circadian rhythms at baseline (within 2-3 days of admission) and at 10-14 days (at discharge).
Related Therapeutic Areas
Sponsors
Leads: Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health