Evaluation of Cortico-Cerebellar Network Properties As Biomarkers for the Responsiveness to Cortico-Cerebellar Brain Stimulation in Stroke Patients
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The present study will evaluate the potential of cortico-cerebellar network properties derived from neuroimaging in a group of chronic stroke patients to explain inter-subject variability in responsiveness to transcranial direct current stimulation (tDCS) targeting the cortico-spinal and cortico-cerebellar network.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• patients after first-ever clinical ischemic stroke in the early (\>3 month) or later chronic (\>6 months) stage of recovery
• persistent motor deficit of the upper extremity
• stroke location: supratentorial
• age \> 18 years
• written informed consent obtained
Locations
Other Locations
Germany
University Medical Center Hamburg-Eppendorf, Dept. of Neurology
RECRUITING
Hamburg
Contact Information
Primary
Robert Schulz, PD Dr. med.
rschulz@uke.de
0049-40-7410-0
Time Frame
Start Date: 2022-07-01
Estimated Completion Date: 2026-07-01
Participants
Target number of participants: 81
Treatments
Active_comparator: Anodal M1 tDCS
20 minutes of anodal tDCS (C3 or C4 depending on side of lesion) to the ipsilesional M1: 2mA Combined with 45min of structured motor training.
Active_comparator: Combined M1 and cerebellar anodal tDCS
20 minutes of anodal tDCS (C3 or C4 depending on side of lesion) to the ipsilesional M1 combined with contralesional cerebellar montage (2cm lateral to Inion): 2mA per anode Combined with 45min of structured motor training.
Sham_comparator: Sham tDCS
Sham stimulation. Combined with 45min of structured motor training.
Related Therapeutic Areas
Sponsors
Leads: Universitätsklinikum Hamburg-Eppendorf
Collaborators: German Research Foundation