A Randomized Controlled Clinical Trial of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke. Previous study also revealed that 53.4% of people after stroke experienced cognitive impairment. Different cognitive domains might be affected following stroke, such as attention, memory, language, and orientation, and the problems with memory are often prominent. Yet, there is no effective treatment for the post-stroke cognitive impairment. Transcutaneous spinal cord stimulation (tSCS) and transcutaneous vagus nerve stimulation (tVNS) are simple and non-invasive treatment to improve upper limb motor function and cognitive function. However, no existing studies have explored on the effects of tSCS and tVNS on cognitive function in people with stroke. Therefore, the purpose of this study is to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) on improving upper limb function and cognitive function in people with chronic stroke.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:

• aged between 50 and 80;

• have suffered from a single stroke at least 6 months;

• had volitional control of the non-paretic arm and at least minimal antigravity movement in the paretic shoulder;

Locations
Other Locations
Hong Kong Special Administrative Region
The Hong Kong Polytechnic University
RECRUITING
Hong Kong
Contact Information
Primary
Shamay NG, PhD
shamay.ng@polyu.edu.hk
+852 27664889
Time Frame
Start Date: 2023-11-01
Estimated Completion Date: 2025-12-15
Participants
Target number of participants: 90
Treatments
Experimental: tSCS
The participants will be received eighteen 45-minute sessions of intervention, 3 sessions per week for 6 weeks.
Experimental: tVNS
The participants will be received eighteen 45-minute sessions of intervention, 3 sessions per week for 6 weeks.
Placebo_comparator: Control
The participants will be received eighteen 45-minute sessions of intervention, 3 sessions per week for 6 weeks.
Related Therapeutic Areas
Sponsors
Leads: The Hong Kong Polytechnic University

This content was sourced from clinicaltrials.gov