Contrast Enhanced Ultrasound and Elastography of the Neonatal Brain
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain perfusion. We use contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography to evaluate the state of brain perfusion. We will study neonates recruited from the Neonatal Units of Turku University Hospital.
Eligibility
Participation Requirements
Sex: All
Minimum Age: Newborn
Maximum Age: 6 months
Healthy Volunteers: f
View:
• Babies less than 7 months treated at the neonatal units of Turku University hospital
Locations
Other Locations
Finland
Turku University Hospital
RECRUITING
Turku
Contact Information
Primary
Tiina Laurikainen
tiina.laurikainen@tyks.fi
+35823135941
Backup
Riitta Parkkola
riitta.parkkola@tyks.fi
+35823130148
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2029-12
Participants
Target number of participants: 100
Treatments
Active_comparator: Term neonates
Diagnostic Test: Brain ultrasound, brain contrast enhanced ultrasound, brain ultrasound elastography, cardiac ultrasound To study brain perfusion with brain ultrasound, contrast enhanced ultrasound of the brain and ultrasound-guided shear-wave elastography Drug: Sulfur Hexafluoride To evaluate brain perfusion in infants with no suspected brain pathology using CEUS. Later, different patient groups could be compared to infants with no suspected brain pathology.~Other Names:~• SonoVue
Experimental: Neonatal asphyxia
Diagnostic Test: Brain ultrasound, brain contrast enhanced ultrasound, brain ultrasound elastography To study brain perfusion with brain ultrasound, contrast enhanced ultrasound of the brain and ultrasound-guided shear-wave elastography Drug: Sulfur Hexafluoride To evaluate brain perfusion in neonates after birth asphyxia~Other Names:~• SonoVue
Experimental: Neonatal stroke
Diagnostic Test: Brain contrast enhanced ultrasound, brain ultrasound elastography To study brain perfusion with brain ultrasound, contrast enhanced ultrasound of the brain and ultrasound-guided shear-wave elastography Drug: Sulfur Hexafluoride To evaluate brain perfusion after neonatal stroke~Other Names:~• SonoVue
Experimental: Other neonatal brain pathologies
Diagnostic Test: Brain ultrasound, brain contrast enhanced ultrasound, brain ultrasound elastography To study brain perfusion with brain ultrasound, contrast enhanced ultrasound of the brain and ultrasound-guided shear-wave elastography Drug: Sulfur Hexafluoride To evaluate brain perfusion in infants with other type (no asphyxia, stroke or preterm birth related) of brain pathology, like hydrocephalus, hemorrhage or central nervous system infection~Other Names:~• SonoVue
Related Therapeutic Areas
Sponsors
Leads: Turku University Hospital