Magnetic Resonance Imaging Evidence of Cardiac Inflammation Post-Stroke
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left (n=22) MCA territories and 24 control patients with acute focal neurological symptoms but no evidence of acute brain infarct on DWI-MRI.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• • Acute ischemic stroke in the right or left MCA territory. Acute ischemic stroke is defined as acute onset focal symptoms matching an acute brain infarct documented on Head computed tomography or diffusion-weighted imaging (DWI) MRI of the brain showing restricted diffusion.
Locations
Other Locations
Canada
Heart & Brain Lab, Western University
RECRUITING
London
Contact Information
Primary
Diana Ayan, MSc
diana.ayan@lhsc.on.ca
+1 519.685.8500
Backup
Jennifer Moussa
jennifer.moussa@lhsc.on.ca
+1 519.685.8500
Time Frame
Start Date: 2021-10-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 44
Treatments
Cases (Ischemic stroke): Left and right middle cerebral artery ischemic stroke
Patients presenting with acute onset focal neurological deficits and DWI-MRI evidence of an acute brain infarct of the left or right middle cerebral artery ischemic stroke.
Controls (TIA): Patients with acute focal neurological symptoms without brain infarct on MRI.
Patients presenting with acute onset focal neurological deficits presumed to be of vascular origin, WITHOUT DWI-MRI evidence of an acute brain infarct.
Related Therapeutic Areas
Sponsors
Collaborators: Western University, Canada, McMaster University
Leads: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's