Intravenous Adjuvant With Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Acute Ischemic Stroke Patients With Large Vessel Occlusion: a Multicenter, Open Label, Randomized Controlled Trial.
In patients with acute ischemic stroke secondary to large vessel occlusion, the role of intravenous adjunctive medications, such as tirofiban, or alteplase before endovascular thrombectomy has not been well investigated. This trial aim to evaluate the efficacy and safety of intravenous tirofiban versus alteplase for acute ischemic stroke patients with large vessel occlusion piror to endovascular thrombectomy.
• Aged 18 years or older.
• Presenting with acute ischemic stroke symptom.
• Time from onset to hospital arrival:
‣ (1) within 4.5 hours
⁃ (2) 4.5-9.0 hours, image inclusion criteria for the EXTEND trial must be met
⁃ (3) \> 4.5 hours but within 24 hours, image inclusion criteria for the WAKE-UP trial must be met.
• Eligible for intravenous thrombolysis.
• Occlusion of the internal carotid artery, M1 or M2 segment of the middle cerebral artery, vertebrobasilar artery confirmed by CTA, MRA, or DSA.
• Informed consent obtained from patients or their legal representatives.