Strengthening Task Specific Activation of Paretic Hand Muscles After moderate-to- Severe Chronic Stroke

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Researchers at the University of Pittsburgh are conducting a research study to see how combining brain, nerve, and hand stimulation affect hand movement after stroke. The primary purpose of this study is to examine changes in the connection between the brain and the weak hand muscles after the combined brain, nerve, and hand stimulation. The primary hypothesis is that the combined brain, nerve, and hand stimulation will increase the the connection between the brain and the weak hand muscles. The secondary purpose of this study is to examine changes in weak hand's movement and function after the combined brain, nerve, and hand stimulation. The secondary hypothesis is that the combined brain, nerve, and hand stimulation will increase weak hand movement and function.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Age between 18-85 years

• Diagnosis of first-ever subcortical stroke (single cerebrovascular accident)

• Stroke onset of at least six months prior to the time of participation

• A score of at least 1 out of 2 on the spherical grasping item of the Fugl-Meyer Upper Extremity Subscale to allow participants to grasp the ball

• Cognitive skills to actively participate, as indicated by scores of \> 23 on the Mini-Mental Status Examination

• English speaking

Locations
United States
Utah
Neural Plasticity Rehabilitation and Movement Dynamics Lab
RECRUITING
Salt Lake City
Contact Information
Primary
Amit Sethi, PhD
amit.sethi@utah.edu
8016467882
Time Frame
Start Date: 2023-06-29
Estimated Completion Date: 2026-01-30
Participants
Target number of participants: 40
Treatments
Experimental: Task-specific PCMS, PCMS-rest, Task-specific sham-PCMS
During Task-specific paired corticospinal-motor neuronal stimulation (PCMS) participants will receive PCMS \[Transcranial Magnetic Stimulation (TMS) + Peripheral Nerve Stimulation (PNS)\] with task-specific practice.~During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.~During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS).
Experimental: Task-specific PCMS, Task-specific sham-PCMS, PCMS-rest
During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.~During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.~During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS).
Experimental: PCMS-rest, Task-specific PCMS, Task-specific sham-PCMS
During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.~During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.~During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS).
Experimental: PCMS-rest, Task-specific sham-PCMS, Task-specific PCMS
During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.~During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.~During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS).
Experimental: Task-specific sham-PCMS, Task-specific PCMS, PCMS-rest
During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.~During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.~During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS).
Experimental: Task-specific sham-PCMS, PCMS-rest, Task-specific PCMS
During Task-specific PCMS participants will receive PCMS (TMS + PNS) with task-specific practice.~During PCMS rest participants will receive PCMS (TMS + PNS) without task-specific practice.~During Task-specific sham-PCMS participants will receive task-specific practice with sham PCMS (TMS + PNS).
Related Therapeutic Areas
Sponsors
Leads: University of Utah
Collaborators: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

This content was sourced from clinicaltrials.gov

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