Trophic Enteral Feeding Combined With Supplemental Parenteral Nutrition Treatment in Patients With Severe Stroke (OPENS-2): a Multicentre, Prospective, Randomised, Open-label, Blinded-endpoint Trial
Post stroke pneumonia (PSP) is one of the common early complications of stroke. Post-stroke infections, in general, are associated with less favorable neurologic outcomes. Aspiration is one of the most feared complications of enteral nutrition and can lead to the occurrence of pneumonia. Severe stroke patients are at high risk for aspiration due to some factors such as the reduced level of consciousness, inability to protect the airway and so on. The purpose of this study is to explore the ideal nutrition support strategy for patient with acute severe stroke to help reduce the incidence of PSP and improve the prognosis.
• Age≥18 years
• Definite diagnosis of acute stroke (GCS ≤12 or NIHSS≥11)
• The randomized nutritional treatment could be initiated up to 72 hours after symptom onset.
• Any cases of profiles #3 through 5 in Water Swallowing Test or with disorder of consciousness.
• Plan to receive nutritional support treatment for at least 7 days.
• Informed consent.