Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Status: Recruiting
Location: See all (13) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA
• Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen
Locations
United States
Alabama
University of Alabama Hospital
RECRUITING
Birmingham
Connecticut
Yale New Haven Hospital
NOT_YET_RECRUITING
New Haven
Washington, D.c.
MedStar Washington Hospital Center
NOT_YET_RECRUITING
Washington D.c.
Florida
Baptist Medical Center Jacksonville
RECRUITING
Jacksonville
Jackson Memorial Hospital, Miami
RECRUITING
Miami
Illinois
SIH Memorial Hospital of Carbondale
NOT_YET_RECRUITING
Carbondale
University of Chicago Medical Center
RECRUITING
Chicago
University of Illinois Hospital
RECRUITING
Chicago
Missouri
Barnes Jewish Hospital
RECRUITING
St Louis
North Carolina
Carolinas Medical Center
NOT_YET_RECRUITING
Charlotte
New York
Buffalo General Medical Center
RECRUITING
Buffalo
North Shore University Hospita
RECRUITING
Manhasset
Ohio
UH Cleveland Medical Center
RECRUITING
Cleveland
Contact Information
Primary
Ka-Ho Wong
ka-ho.wong@hsc.utah.edu
801-585-7575
Backup
Amy Sulken
sulkenay@ucmail.uc.edu
Time Frame
Start Date:2024-06-24
Estimated Completion Date:2029-03-31
Participants
Target number of participants:300
Treatments
CAPTIVA-MRI Group
CAPTIVA patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.