The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Patients With Heat Stroke

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke. The main question it aims to answer is whether limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke. Participants will receive a free normal saline infusion during the emergency department according to the study design, or a restricted normal saline infusion while using sodium lactate Ringer's instead. Researchers will compare the normal saline infusion group and sodium lactate Ringer's group to see if limiting the amount of normal saline infusion during emergency department can lower the incidence of acute kidney injury and mortality in patients with heat stroke.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• ≥ 18 years

• diagnosed as heat stroke

• Informed consent from patients or family members.

Locations
Other Locations
China
Dongyang People's Hospital
RECRUITING
Dongyang
YongKang First People's Hospital
RECRUITING
Guli
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING
Hangzhou
Jinhua Municipal Central Hospital
RECRUITING
Jinhua
Jinhua People's Hospital
RECRUITING
Jinhua
Lanxi People's Hospital
RECRUITING
Lanxi
Yiwu Central Hospital
RECRUITING
Yiwu
Contact Information
Primary
Xiuqin Feng, PRO
fengxiuqin@zju.edu.cn
8613757119151
Backup
Lan Chen, PHD
jhchenlan2003@hotmail.com
+8613819987120
Time Frame
Start Date: 2023-05-28
Estimated Completion Date: 2026-03
Participants
Target number of participants: 190
Treatments
Active_comparator: Normal Saline infusion group
During the emergency department, the normal saline infusion was not restricted.
Experimental: Ringer lactate infusion group
Use ringer lactate or other balanced crystallographic solution instead of normal saline. Strictly limit the amount of normal saline infusion. Normal saline will only be infused by medical advice if the patient has hypochloremia or needs saline as solvent.
Related Therapeutic Areas
Sponsors
Leads: Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborators: Yiwu Central Hospital, Dongyang People's Hospital, Lanxi People's Hospital, Jinhua Municipal Central Hospital, Jinhua People's Hospital

This content was sourced from clinicaltrials.gov