Blood Flow Regulation and Neuromuscular Function Post-Stroke

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Be between 18-85 years of age

• Able to give informed consent

• ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke

• English speaking

Locations
United States
Wisconsin
Marquette University
RECRUITING
Milwaukee
Medical College of Wisconsin
RECRUITING
Milwaukee
Contact Information
Primary
Matthew Durand, Ph.D.
mdurand@mcw.edu
4149555619
Backup
Jennifer Nguyen, BS
jnguyen@mcw.edu
Time Frame
Start Date: 2024-01-11
Estimated Completion Date: 2028-06-30
Participants
Target number of participants: 40
Treatments
Experimental: Ischemic Conditioning
Ischemic conditioning is a well-defined, non-invasive procedure which consists of inflating a blood pressure cuff around a limb (in our study, the paretic leg), inflating the cuff to 225 mmHg to occlude blood flow to the limb for 5 minutes, releasing the cuff for 5 minutes, and repeating 5 times. In our study, participants will receive six sessions of ischemic conditioning over the course of two weeks.
Sham_comparator: Ischemic Conditioning Sham
There will also be an IC Sham group which is identical to the IC intervention, except the cuff will only be inflated to 10 mmHg, which is not a high enough pressure to occlude arterial blood flow.
Related Therapeutic Areas
Sponsors
Leads: Medical College of Wisconsin

This content was sourced from clinicaltrials.gov