Transcranial Alternating Current Stimulation (tACS) to Enhance Language Abilities
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aphasia group with aged matched controls to see if brain response to tACS differs between groups.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: t
View:
• Presence of aphasia
• Suffered a single, left hemisphere stroke
• Stroke ≥6 months old (chronic) at the time of enrollment
• Right-handedness
• Must be able to understand the nature of the study, and give informed consent
Locations
United States
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
Contact Information
Primary
Daniela Sacchetti, MS
danielas@pennmedicine.upenn.edu
215 573 4336
Backup
Denise Harvey, PhD
harveyde@pennmedicine.upenn.edu
215 573 4336
Time Frame
Start Date: 2024-07-12
Estimated Completion Date: 2028-08-31
Participants
Target number of participants: 120
Treatments
Active_comparator: real-tACS
The active stimulation will consist of an alternating current delivered in the alpha frequency band with a peak-to-peak intensity of 4 milliamps (mA) for 20 minutes. Participants will complete sentence completion and verb generation task during stimulation.
Placebo_comparator: sham-tACS
Sham stimulation involves the delivery of 60 seconds of the actual stimulation waveform (ramp up) which is then gradually reduced to 0 milliamps (mA) (ramp down). Participants will complete sentence completion and verb generation task during stimulation.
Related Therapeutic Areas
Sponsors
Leads: University of Pennsylvania