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Effect of Brain Stimulation on Locomotor Skill Acquisition in Stroke

Status: Recruiting
Location: See location...
Intervention Type: Combination product
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Recent studies showed that a non-invasive, low-intensity brain stimulation called transcranial direct current stimulation (tDCS) can effectively increase motor neuron excitability in the brain and therefore promotes functional recovery after stroke. Thus, the overall purpose of this research project is to examine the effect of brain stimulation on motor skill learning in stroke survivors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 90
Healthy Volunteers: t
View:

• Age between 21 and 90 years

• Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment

• MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract

• Hemiparesis involving the lower extremity (Fugl-Meyer Lower Extremity Motor Test)

• No passive range of motion limitation in bilateral hips and knees

• Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less

• Visual acuity can be corrected by glasses or contact lens to 20/20

• Able to walk independently with/without assistant devices for 10 meters

• Able to maintain standing position without any assistance \>= 30 sec (Short Physical Performance Battery)

• Evaluation of cognitive status: Mini-mental status examination (MMSE) score ≥ 24

Locations
United States
Texas
University of Texas Medical Branch
RECRUITING
Galveston
Contact Information
Primary
Shih-Chiao Tseng, PhD
shtseng@utmb.edu
409-772-9555
Time Frame
Start Date: 2025-05-01
Estimated Completion Date: 2027-08-31
Participants
Target number of participants: 70
Treatments
Experimental: To explore the effect of brain stimulation on locomotor skill acquisition in stroke survivors
To explore the trends of locomotor skill acquisition in stroke survivors after anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after sham tDCS (s-tDCS), and stroke with no brain stimulation (control; CON).
Experimental: To explore improvements in learning capacity between healthy adults and stroke participants.
Compare stimulation-induced improvements in learning capacity between three groups: stroke group, healthy young group, and healthy older group.
Experimental: To explore the trends of functional improvements after single a-tDCS session in stroke survivors.
To explore functional improvements (gait performance, brain neural activation) between a-tDCS, s-tDCS, and control groups.
Experimental: To explore the accumulated effects of brain stimulation on gait improvements in stroke survivors
To explore the accumulated, longitudinal trends of a four-week visuomotor stepping training in conjunction with brain stimulation on treadmill walking training and gait improvements for persons with chronic stroke.
Related Therapeutic Areas
Sponsors
Leads: The University of Texas Medical Branch, Galveston
Collaborators: The Claude D. Pepper Older Americans Independence Centers

This content was sourced from clinicaltrials.gov