Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion: A Prospective, Randomized, Double-blind, Placebo-controlled, Multi-center Study
The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.
• Participant with acute anterior circulation ischemic stroke receiving endovascular treatment within 24 hours (non-bridged).
• Age ≥18 years old.
• The mRS score was 0-1 before onset.
• ASPECT score of infarction on emergency CT ≥7.
• Emergency CTA indicating AIS with large vessel occlusion (internal carotid artery, M1 or M2 segment of middle cerebral artery).
• Emergency CTP or DWI suggesting infarct core body ≥10 mL and \<100 mL, and low perfusion brain tissue volume/ infarct core volume\> 1.2.
• Participant is willing and able to comply with the study protocol, and sign the informed consent form (patient or surrogate).