Effects of Medical Treatment of Intracranial Atherosclerotic Diseases Based on Magnetic Resonance Fractional Flow Reserve
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
This multicenter prospective cohort study aims to compare the difference in the effects of medical treatment within 1 year between the two groups of ICAS patients divided hemodynamically by Magnetic Resonance Fractional Flow Reserve. PC MRA will be applied for FFR measurement. The primary outcome is the composite of ischemic stroke or death related to the qualifying artery territory for 1 year.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 80
Healthy Volunteers: f
View:
• Patients aged from 30 to 80 with symptomatic ICAS lesion in anterior circulation.
• 50% to 99% stenosis (in accordance with modified WASID method) confirmed by DSA, CTA or MRA.
• mRS 0-2 points
• Informed of the study protocol and objectives.
Locations
Other Locations
China
Xuanwu Hospital, Capital Medical University
RECRUITING
Beijing
Contact Information
Primary
Jichang Luo
luojichang_dr@sina.com
+8613120136577
Time Frame
Start Date: 2023-01-01
Estimated Completion Date: 2024-06
Participants
Target number of participants: 400
Treatments
Decompensated blood flow reserve
ICAS patients with decompensated cerebral blood flow reserve diagnosed by MR-FFR (FFR baseline≥0.81).
Normal blood flow reserve
ICAS patients with normal cerebral blood flow reserve determined by MR-FFR (FFR baseline\<0.81).
Related Therapeutic Areas
Sponsors
Collaborators: National Key Research and Development Project, China
Leads: Xuanwu Hospital, Beijing