Dynamic Changes in Human Microbiome Predict the Risk of Adverse Outcomes in Patients With Acute Ischemic Stroke: a Multicenter Prospective Cohort Study
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
(1) The main purpose To explore the predictive value of human microbiome and its metabolome for adverse prognosis in patients with acute ischemic stroke (AIS). (2) Secondary purposes 1. To explore the characteristics of cross-regional disturbance of human microbiome in stroke patients; 2. To investigate the characteristics and rules of bacterial flora changes before and after recurrent apoplexy; 3. Markers closely related to AIS prognosis and cognitive emotional complications were excavated by metagenomic, metabolic, peptide and imaging groups. 4. To explore the relationship between serum markers of ultra early stage and prognosis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:
• Meet the diagnostic criteria for AIS or TIA
• Age 18-80 years old
• Within 7 days of the onset of stroke
• Sign informed consent, provide relevant medical history and biological specimens
• Have lived in the local city for the last three years
Locations
Other Locations
China
Zhujiang Hospital of Southern Medical University
RECRUITING
Guangzhou
Contact Information
Primary
Mengxi Li
1135621389@qq.com
15013048680
Time Frame
Start Date:2022-02-10
Estimated Completion Date:2025-12-30
Participants
Target number of participants:2000
Treatments
AIS patient
AIS inclusion criteria~(1) Inclusion criteria~1. Meet the diagnostic criteria for AIS or TIA;~2. Age 18-80 years old;~3. within 7 days of the onset of stroke;~4. Sign informed consent, provide relevant medical history and biological specimens;~5. Have lived in the local city for the last three years.~(2) Exclusion criteria~1. Patients with recurrent stroke within the past year when first enrolled;~2. mRS \> 2 points before stroke onset;~3. malignant tumor;~4. Liver and kidney dysfunction (alanine aminotransferase or aspartate aminotransferase \>2 times the upper limit of normal, creatinine \> 1.5 times the upper limit of normal);~5. History of drug abuse and chemical poisoning (e.g. pesticide poisoning);~6. In the acute stage of stroke (within 7 days from the onset of stroke) stool specimens could not be collected.
Cognitive/emotional subcohort
(I) Inclusion criteria:~1. It has been included in the AIS queue, meeting the inclusion criteria of the main AIS queue;~2. NIHSS≤15; (II) Exclusion criteria:~(1) Patients with aphasia and unable to cooperate in completing the cognitive/emotional assessment during the study; (2) previous severe mental disorder and dementia (AD8 scale score ≥2); (3) A history of severe anxiety and depression; (4) Previous history of seizures.