Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions ( CMI )

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Cerebral cortical microinfarctions (CMI) are frequently observed on MRI and histology studies, especially in elderly patients and in patients with cognitive dysfunction. The majority of these studies analysed chronic cerebral CMI lesions. The few studies reporting on temporal dynamics of MRI signal of acute cerebral CMI showed very low sensibility for persisting signal changes on follow-up MRI on standard MRI sequences. A retrospective study, analysing follow-up 3T MRI in 25 patients with acute cerebral CMI (defined as ≤10 mm on DWI), showed a chronic cerebral CMI detection rate of only 16% on T2-weighted and 5% on FLAIR imaging after a mean follow-up period of 33 months (with a very wide range of 0.5-142 months). Another 3T MRI study including seven patients showed disappearance of all acute cerebral very small-sized CMI (defined as \<5 mm size on initial DWI) on all follow-up MRI sequences (T1- and T2-weighted and FLAIR imaging, performed after one month). Recently, it has been shown that chronic relatively small (\<20 mm) cerebellar cortical infarctions (based on diffusion-weighted imaging) were frequently observed in acute stroke patients, especially in case of cardioembolic stroke (with chronic small cerebellar cortical infarctions observed in 32% of cases). The high prevalence of these chronic small cerebellar cortical infarctions suggest a possible higher detection rate of chronic small-sized infarction in the cerebellum compared to the supratentorial brain.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
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⁃ Patients admitted to our stroke centre between February 2021 and June 2023 with the following inclusion criteria:

• age \>18 years,

• initial MRI performed within one week after symptom onset,

• symptomatic brain infarction confirmed by DWI,

• presence of acute cerebral and/or cerebellar CMI

Locations
Other Locations
France
CHU de Nîmes
RECRUITING
Nîmes
Contact Information
Primary
Dimitri RENARD
dimitri.renard@chu-nimes.fr
+33466685808
Time Frame
Start Date: 2024-02-15
Estimated Completion Date: 2024-12
Participants
Target number of participants: 59
Treatments
acute cerebral and/or cerebellar CMI
Patients with acute cerebral and/or cerebellar CMI
Related Therapeutic Areas
Sponsors
Leads: Centre Hospitalier Universitaire de Nīmes

This content was sourced from clinicaltrials.gov