Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates Such as Pulse Pressure Variation (PPV), End-tidal CO2 (Carbon Dioxide), Bioreactance (Stroke Volume Index -SVI) and Velocity Time Integral on Echocardiographic Exam for Fluid Responsiveness in Patients With Moderately Severe ARDS (Acute Respiratory Distress Syndrome)

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 90
Healthy Volunteers: f
View:

• Age between 30 - 90 years

• Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension

• Diagnosis of ARDS with PF ratio \< 150 , PEEP \> 8

• Patients who are under paralysis or deeply sedated, on a mechanical ventilator

Locations
United States
Minnesota
St Cloud Hospital
RECRUITING
Saint Cloud
Contact Information
Primary
Ramakanth Pata
cookybrey1@gmail.com
320-240-2207
Time Frame
Start Date: 2023-07-01
Estimated Completion Date: 2025-06
Participants
Target number of participants: 64
Treatments
Fluid responder
Stability of vasopressor dose with maximum of 500 cc of crystalloids
Fluid non responder
Escalating dose of vasopressors despite 1 L of crystalloid fluid challenge
Sponsors
Leads: CentraCare

This content was sourced from clinicaltrials.gov