Immediate Angioplasty For Acute Ischemic Stroke With Severe Intracranial Atherosclerotic Stenosis (MAGIC): A Multicenter, Prospective, Open-label, Blinded Endpoint, Randomized Controlled Trial
A multicenter, prospective, open-label, blinded endpoint, randomized controlled trial that aims to evaluate the effect of immediate angioplasty (with or without stenting) for acute ischemic stroke (AIS) with severe intracranial atherosclerotic stenosis (ICAS) in improving the 90-day functional outcome.
• Aged 18 years or older.
• Diagnosed with AIS and baseline NIHSS ≥6.
• Pre-stroke mRS ≤2.
• Time from symptom onset to randomization ≤ 24 hours; the onset time refers to Last Known Well (LKW).
• Non-contrast CT ASPECTS score ≥6.
• CTA confirmed severe ICAS (70-99%) of the intracranial segment of the internal carotid artery, or M1 or M2 segment of the middle cerebral artery, and is presumed to be responsible for the stroke.
• Informed consent signed by the patient or authorized representative.