Towards Real-time Personalized Brain State-dependent TMS to Enhance Poststroke Hand Rehabilitation

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic hand function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and hand motor impairment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• History of stroke \>6 months ago

• Presence of residual upper extremity hemiparesis

• Willingness to participate

• Ability to provide informed consent

• Upper extremity Fugl-Meyer score \< 66

• Mini Mental State Exam score \> 24

• Discernable and reliable motor-evoked potential (MEP) following single-pulse transcranial magnetic stimulation to the lesioned hemisphere

Locations
United States
Texas
University of Texas at Austin
RECRUITING
Austin
Contact Information
Primary
Sara J Hussain, PhD
sara.hussain@austin.utexas.edu
512-232-2686
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2026-08-31
Participants
Target number of participants: 37
Treatments
Experimental: Brain state-dependent TMS during strong states
Active_comparator: Brain state-dependent TMS during random states
Related Therapeutic Areas
Sponsors
Leads: University of Texas at Austin

This content was sourced from clinicaltrials.gov