Effect of Preoperative Stroke Volume Optimization Using Transthoracic Echocardiography on Arterial Hypotension Following Induction of Intravenous Anesthesia. A Prospective, Double Blinded Randomized Study.

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Immediately following the induction of general anesthesia, arterial hypotension may occur with an incidence of about 40% in patients classified as ASA 3 or 4. Perioperative arterial hypotension is associated with increased perioperative morbidity and mortality. The increased mortality associated with perioperative arterial hypotension has been reported up to 30 and 90 days after surgery. This association appears to be both dose-dependent and time-dependent (severity and duration of arterial hypotension). EchOptimal study aims to determine whether non invasive preoperative stroke volume optimization using transthoracic echocardiography (TTE) can reduce the incidence and severity arterial hypotension following induction of general anesthesia. This is prospective, randomized, controlled, double blinded study approved by ethics comittee. The primary objective of this study is to compare the incidence of arterial hypotension (mean arterial pressure \< 65 mmHg) within the first 15 minutes following the induction of general anesthesia, between 2 groups : * standard current care (stroke volume optimized after induction of general anesthesia using oesophageal doppler) and * preopertaive stroke volume optimization using transthoracic echocardiography measument of subaortic velocity time integral.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: f
View:

• Patient aged 18 years or older,

• Affiliated with social security,

• Informed about the study and having signed the informed consent form,

• Requires surgical intervention under general anesthesia,

• Intermediate or high risk of cardiovascular events within 30 days,

• ASA phyiscal status Classification 3 or 4

Locations
Other Locations
France
Universty Hospital of Caen
RECRUITING
Caen
Contact Information
Primary
jean-luc HANOUZ, MD PhD
hanouz-jl@chu-caen.fr
02 31 06 47 36
Time Frame
Start Date: 2024-10-04
Estimated Completion Date: 2027-12-30
Participants
Target number of participants: 220
Treatments
Active_comparator: control
Standard care : total intravenous anesthesia followed by stroke volume optimization using oesophageal doppler
Experimental: preoperative echography
Stroke volume optimization using transthoracic echocardigraphy (sub aortic velocity time integral) before induction of total intravenous anesthesia
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Caen

This content was sourced from clinicaltrials.gov

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