Evaluation of the Effect of Statins on the Incidence of Side Effects of Platinum Based Chemotherapy in Patients With Solid Tumors

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

Platinum based chemotherapy (mainly Cisplatin) is known to cause a variety of adverse effects, including Ototoxicity and nephrotoxicity. Ototoxicity is estimated to affect about 36% of adult patients treated with cisplatin, many therapeutic interventions have been studied to reduce the risk of developing ototoxicity from Cisplatin treatment, Statins have been studied in animals and have shown promising results, this study is aimed to explore the effect of statins on the incidence of ototoxicity in humans.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Patients will receive platinum based chemotherapy.

• Eastern Cooperative Oncology Group (ECOG) performance status from 0 to 2.

Locations
Other Locations
Egypt
Minia University hospital, department of oncology and nuclear medicine
NOT_YET_RECRUITING
Minya
Minia University hospital, department of oncology and nuclear medicine
RECRUITING
Minya
Contact Information
Primary
Noha H. Mohamed Helmy, Masters
noha.hassan@mu.edu.eg
+20 1023008427
Backup
Fatma M. Madi, professor
fatmamady@hotmail.com
+20 1028733768
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 60
Treatments
Placebo_comparator: control group
placebo once daily for treatment period
Experimental: intervention group
study drug once daily for treatment period
Related Therapeutic Areas
Sponsors
Leads: Minia University

This content was sourced from clinicaltrials.gov