Evaluation of 3 Patterned rTMS Stimulation Dosage on Corticospinal Excitability and Motor Learning in Stroke Patients
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The study is about using a brain stimulation technique called rTMS (Repetitive Transcranial Magnetic Stimulation) to help improve hand muscles in people who had a stroke. Researchers want to understand how this device can help stroke patients use their hands better.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Healthy Volunteers: f
View:
• Age \>=21 years old of any race or gender
• First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from stroke onset
• Unilateral arm weakness measured by FM-UM scale \<= 62/64
• Inducible rest motor threshold and testing motor threshold recorded from the affected first dorsal interosseous (FDI) muscle from the study subject
Locations
United States
North Carolina
Duke University Medical Center
RECRUITING
Durham
Contact Information
Primary
Wuwei Feng, MD
wayne.feng@duke.edu
919 681 1700
Backup
Megan N Gonzalez, MS
megan.gonzalez@duke.edu
9196687597
Time Frame
Start Date: 2025-06-09
Estimated Completion Date: 2027-04-30
Participants
Target number of participants: 26
Treatments
Experimental: Non-invasive Brain Stimulation Modalities
All participants will undergo three non-invasive brain stimulation modalities:~1. Focal conventional iTBS over the ipsilesional motor cortex (i.e., a single bout of 600 pulses over a single spot; FiTBS600).~2. Focal high dose iTBS over the ipsilesional motor cortex (i.e. 4 bouts of 600 pulses over a single spot = 2400 pulses; FiTBS2400).~3. Diffuse high dose iTBS over the ipsilesional motor cortex (i.e. 4 bouts of 600 pulses over 4 spots: 600 pulses/spot × 4 spots = 2400 pulses; DiTBS2400)
Related Therapeutic Areas
Sponsors
Leads: Duke University