Health Effects of Vitamin K2 and Zinc Supplementation on Skeletal Muscle and Neurological Function After Ischemic Stroke
The primary goal of this clinical trial is to assess whether vitamin K2 or zinc supplementation can effectively improve skeletal muscle and neurological function in patients with ischemic stroke. The main questions it aims to answer are: 1. Does supplementation with vitamin K2 or zinc improve the subjects' muscle strength and muscle mass? 2. Can supplementation with vitamin K2 or zinc improve the subjects' neurological function after a stroke? Researchers will compare vitamin K2 or zinc supplements with a placebo to observe whether vitamin K2 or zinc supplementation can improve skeletal muscle and neurological function in patients with ischemic stroke. Participants will: 1. Take vitamin K2 (MK-7), zinc supplements, or a placebo daily for 2 years. 2. Attend face-to-face visits and provide biological samples and relevant data at 0, 3, 6, 9, 12, and 24 months (intervention phase). After the intervention, follow-up will continue for 1 year to observe the long-term effects.
⁃ Participants who meet all the following conditions will be included in the trial:
• Men or women aged ≥ 18 years.
• Patients with recent ischemic stroke（first or recurrent stroke no more than 7 days before admission）without significant residual limb paralysis, NIHSS score between 2-15, and muscle strength graded 2-4.
• The patient and their legal guardian (or legally acceptable representative) voluntarily sign the informed consent form.