The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Background: Light is the most important regulator of circadian rhythm. Naturalistic light, which contains the spectrum of sunlight throughout the day, has been shown to have a positive impact on mental states such as depression and fatigue in stroke and other diseases requiring long-term hospitalization. Depression and fatigue are very common complications after stroke, with a frequency of 30% and 85%, respectively. Both are significantly related to reduced quality of life and early death. Both the causes and pathophysiology behind these complications are unknown, but it is assumed that disturbances (inflammation and cell death) in brain areas and brain networks related to arousal, sleep, circadian rhythm, and the frontal lobe play a role. The hypothesis is that it is possible to detect changes in brain networks related to depression and fatigue by MRI, and that naturalistic light will affect these changes. Method: Stroke patients requiring a minimum of 10 days of rehabilitation are transferred to a neurorehabilitation unit with naturalistic lighting. Examination: Validated tests for fatigue, depression, sleep and cognitive functions. Pathophysiological studies: * MRI focusing on cerebral blood flow, metabolism, and cerebral networks. * Spinal fluid analyses for hormones and markers involved in immunological response as well as wakefulness/arousal and depression. * Sleep assessments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients scoring moderate-severe fatigue and/or depression OR NO fatigue and/or depressione which are evaluated as candidates for the rehabilitation unit.

Locations
Other Locations
Denmark
Faculty of Health and Medical Sciences - University of Copenhagen
RECRUITING
Glostrup Municipality
Contact Information
Primary
Anders Sode West, MD, PhD.
anders.sode.west@regionh.dk
+4538634051
Backup
Helle Iversen, MD, D.M.Sc
helle.klingenberg.iversen@regionh.dk
+4538634051
Time Frame
Start Date: 2025-04-10
Estimated Completion Date: 2030-01-01
Participants
Target number of participants: 45
Treatments
Active_comparator: Moderate-severe depression or/and fatigue
Naturalistic Light Intervention
Active_comparator: No measured depression or/and fatigue
Naturalistic Light Intervention
Related Therapeutic Areas
Sponsors
Leads: Rigshospitalet, Denmark
Collaborators: Chromaviso A/S

This content was sourced from clinicaltrials.gov