Intravenous Tenecteplase Before Interhospital Transfer for Thrombectomy in Acute Basilar Artery Occlusion at 4.5 to 24 Hours
This study is designed to investigate the efficacy and safety of intravenous tenecteplase before interhospital transfer from a non-endovascular capable center(nECC) to an endovascular capable center (ECC) for thrombectomy in patients with acute ischemic stroke (AIS) caused by neuroimaging-confirmed acute basilar artery occlusion (BAO) between 4.5-24 hours of symptom onset.
• 1\. Age ≥18 years; 2. Patients presenting with posterior circulation ischemic stroke symptoms due to BAO; 3. BAO confirmed by computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA); 4. Time from symptom onset to randomization within 4.5-24 hours, stroke onset is defined as the time the patient was last known to be well (including wake-up stroke and unwitnessed stroke); 5. Baseline National Institute of Health Stroke Scale (NIHSS) score obtained prior to randomization ≥6; 6. Functionally independent (modified Rankin Scale \[mRS\] 0-2) prior to stroke onset; 7 Intended to transfer to CSCs for thrombectomy 8. Written informed consent from patients or legally responsible representatives