Immersive Virtual Reality in Cognitive Rehabilitation of Patients With Post-Stroke Cognitive Impairment: A Pilot Study at the Department of Physical Medicine and Rehabilitation, Clinical Hospital of the University of Chile

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This pilot study aims to evaluate the feasibility of implementing immersive virtual reality (VR) in cognitive rehabilitation for adults with post-stroke cognitive impairment receiving outpatient therapy. Participants will use a head-mounted display and interactive software to engage in gamified cognitive exercises that simulate memory, attention, and executive function tasks. The intervention consists of 10 sessions, delivered two to three times per week over a period of approximately four weeks. The study will assess multiple feasibility indicators, including the recruitment rate based on eligibility criteria, the safety and tolerability of VR sessions for participants, and the usability and satisfaction reported by occupational therapists administering the intervention. Additionally, exploratory outcomes include changes in global cognition and specific cognitive domains, as well as self-reported quality of life. Adverse effects related to VR use will be tracked. This pilot study will help inform the design and implementation of future, larger-scale clinical trials.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients over 18 years of age

• Patients with a cerebrovascular accident of any etiology with less than 3 months of progression

• Patients with mild to moderate cognitive impairment post-stroke (impairment in at least one cognitive domain)

• MoCA score of less than 24 points

• Referred for cognitive rehabilitation at the Occupational Therapy Unit of HCUCH

Locations
Other Locations
Chile
Hospital Clinico de la Universidad de Chile
RECRUITING
Independencia
Contact Information
Primary
Natalia Gattini, MD
ngattini@hcuch.cl
+56989019110
Backup
Diego Elizondo, MD
diegoelizondo@ug.uchile.cl
+56951087567
Time Frame
Start Date: 2025-08-06
Estimated Completion Date: 2026-05-01
Participants
Target number of participants: 20
Treatments
Experimental: VR-based Cognitive Rehabilitation
Participants receive cognitive rehabilitation supported by immersive virtual reality using the Meta Quest 3 headset and the Kinesix XR application. Each session lasts 60 minutes, with the first 30 minutes involving VR-based cognitive tasks supervised by an occupational therapist. A total of ten sessions are completed over a period of approximately four weeks, with a frequency of two to three sessions per week. This arm is designed to assess the feasibility, safety, usability, and preliminary effects of VR-assisted rehabilitation in patients with post-stroke cognitive impairment.
Related Therapeutic Areas
Sponsors
Leads: University of Chile

This content was sourced from clinicaltrials.gov