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Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will also follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery. We will assess sleep in detail using questionnaires, a sleep monitor worn on the wrist, a portable brain activity sensor, and a sleep mat. We will assess mental health (neuropsychiatric) symptoms using questionnaires. Participants will be asked to complete these assessments at baseline and at approximately 3-monthly intervals until they reach 12 months post-injury. This data will allow us to explore the types of sleep disruption seen after brain injury and examine the association between sleep and mental health symptoms.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
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• Willing and able to give informed consent for participation in the study.

• Aged 18 years or above.

• At least one week, but less than 12 months post-injury

• Clinical diagnosis of acquired brain injury (stroke, haemorrhage or traumatic).

• Participants with Traumatic Brain Injury will have a Mild (probable) or Moderate-severe (definite) brain injury according to the Mayo classification

• Participants must be willing to consent to us contacting their general practitioner (GP) or direct care team if we have concerns about their mental health

Locations
Other Locations
United Kingdom
Oxford Centre for Integrative Neuroimaging (WIN) FMRIB, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU
RECRUITING
Oxford
Contact Information
Primary
Melanie Fleming, PhD
melanie.fleming@ndcn.ox.ac.uk
00 44 1865 611 461
Backup
Brent Elliott, MBBBS MSc
brent.elliott@keble.ox.ac.uk
00 44 7967 418523
Time Frame
Start Date: 2025-10-10
Estimated Completion Date: 2027-11-30
Participants
Target number of participants: 150
Treatments
Adults with acquired brain injury
We will follow adults with either stroke or traumatic brain injury for one year post-injury to examine the associations between sleep, mental health and motor recovery.
Related Therapeutic Areas
Sponsors
Leads: University of Oxford

This content was sourced from clinicaltrials.gov