Integrating AI in Stroke Neurorehabilitation (AISN)
The AISN multicenter randomized controlled trial will assess the effectiveness of a novel artificial intelligence (AI)-based clinical decision-support system integrated into the Rehabilitation Gaming System (RGS) for home-based post-stroke rehabilitation. Approximately 192 participants ≥6 months post-stroke will be recruited across several European centers and assigned to one of three groups: RGS with AI decision support, RGS without AI, or standard care. The primary outcome is upper limb motor improvement for stroke patients, with secondary measures including cognitive function, independence, quality of life, usability, cost-effectiveness, and AI-based support performance.
• ≥ 6 months post-stroke
• Patients presenting a first-ever ischemic or intracerebral hemorrhagic stroke
• Mild to Moderate unilateral upper limb motor impairment: Medical Research Council proximal and distal upper limb MRC ≥2; Action Research Arm Test: ARAT score \< 50 (0 = no function, 57 = no functional limitation).
• Age \> 18 years old
• Able to sit on a chair or a wheelchair and interact with RGS during an entire session
• Minimal experience with smartphone technology based on the clinician's opinion
• Willing to participate in the RGS therapy
• Sign the Informed Consent Form