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Pain and Itch Neuromodulation: Effects of Offset Analgesia, Placebo, and Nocebo and Topographical Distribution of Itch and Pain Receptors

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. In the first session, we will mark six test areas in your face (three on each side on jaw, cheek, and temple, respectively). Thent a series of measure-ments in each test area will be conducted:measurement of the blood flow in the skin and sensitivity tests to pressure, pinprick and stroke with a brush. In the second session, histamine will be applied in one side of the face. On the other side, cowhage spicules will be applied. After 10 minutes, all the tests will be conducted again. The third session will be identical to the second. However, instead of histamine and spicules, patches containing capsaicin will be applied. In the other side, we will apply patches with placebo (i.e., a non-active patch). After 20 minutes all the tests will be conducted again.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• Healthy men and women

• 18-60 years

• Speak and understand English

Locations
Other Locations
Denmark
Aalborg University
RECRUITING
Gistrup
Contact Information
Primary
Silvia Lo Vecchio
slv@hst.aau.dk
+4521397785
Time Frame
Start Date: 2025-09-17
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 30
Treatments
Experimental: Itch and pain
Related Therapeutic Areas
Sponsors
Leads: Aalborg University

This content was sourced from clinicaltrials.gov