Effects of Transcranial Electrical Stimulation (tES) Combined With Cognitive-motor Dual-task Gait Training on Cortical Activity, Spinal Motoneuron Excitability, Cognition and Motor Performance in Stroke Individuals
Status: Recruiting
Location: See location...
Intervention Type: Other, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dual task gait training in sub-acute (at least 2 weeks after stroke onset) to chronic (within 5 years post-stroke) to investigate the effect on cortical activity, spinal motoneuron excitability, cognition and motor performance. The findings may enhance the evidence to support usages of tES for improvimg cognition, motor performance as well as cortical activity and spinal motoneuron excitability in a clinical setting.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Unilateral stroke individuals aged 18-80 years.
• A first-ever stroke.
• Stroke onset from at least 2 weeks-5 years.
• Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
• Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.
• Ability to read, communicate, follow and understand instructions.
Locations
Other Locations
Thailand
Faculty of Physical Therapy, Mahidol University
RECRUITING
Nakhon Pathom
Contact Information
Primary
Wanalee Klomjai, PhD
wanalee.klo@mahidol.edu
+6624415450
Time Frame
Start Date:2025-12-20
Estimated Completion Date:2027-12-30
Participants
Target number of participants:60
Treatments
Experimental: Active HD-tDCS with conventional physical therapy and CMDT gait training
Participants will receive active tDCS for 20 minutes prior conventional physical therapy and CMDT gait training. They will be receive this intervention for 12 sessions (3 days/week for 4 weeks).
Experimental: Active HD-tACS with conventional physical therapy and CMDT gait training
Participants will receive active tACS for 20 minutes prior conventional physical therapy and CMDT gait training. They will received this intervention for 12 sessions (3 days/week for 4 weeks).
Sham_comparator: Sham stimulation witn conventional physical therapy and CMDT gait training
Participants will receive sham stimulation for 30 minutes prior conventional physical therapy and CMDT gait training. They will received this intervention for 12 sessions (3 days/week for 4 weeks).