Effects of Aerobic Exercise and Daytime Sleep on Neurorehabilitation and Functional Abilities in Multiple Sclerosis: Evidence of Training the Brain in Neurorehabilitation

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Aims: * Investigate the brain's neurophysiological responses and memory effects following a training intervention and, separately, sleep, in the form of a power nap, in individuals with MS. * Examine whether these effects persist beyond the few days previously observed in healthy individuals by implementing a longer-term intervention. * Explore whether the training effect is influenced by disease activity in the brain, such as during relapses and during immunosuppressive treatment. * Assess whether the presence of abnormally reduced cognitive endurance (fatigue) affects the impact of the intervention involving exercise and sleep. The study is based on documented positive effects of physical activity and sleep in both young and older adults, as well as in individuals recovering from stroke. The research thus offers promising perspectives for broader applications within neurorehabilitation, and particularly for MS, as the disease is associated with functional impairments. At the same time, both physical exercise and sleep represent meaningful interventions that should be thoughtfully integrated into rehabilitation strategies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• Competent individuals (aged 18-70) diagnosed with early relapsing-remitting MS

• Expanded Disability Status Score, 1 \< EDSS \< 4.5

• MRC muscle strength ≥ 4+ in the dominant hand

Locations
Other Locations
Denmark
Section of Movement and Neuroscience, Department of Nutrition, Exercise, and Sports, University of Copenhagen
NOT_YET_RECRUITING
Copenhagen
Zealand University Hospital Roskilde
RECRUITING
Roskilde
Contact Information
Primary
Caroline Sadolin Muushardt, MSc
cmuu@regionsjaelland.dk
+45 46323200
Backup
Martin Ballegaard, MD MPG PhD
mbag@regionsjaelland.dk
Time Frame
Start Date: 2025-12-01
Estimated Completion Date: 2028-11-30
Participants
Target number of participants: 20
Treatments
Experimental: Aerobic Exercise - GXT
The aerobic exercise will consist of about 20 minutes of Graded Exercise Training (GXT) on an ergometer bike. The experimenter will instruct and motivate the participant through the aerobic exercise.
No_intervention: Control - Rest
The participant will rest in a sitting position in a quiet room for 20 minutes. The participant is allowed to read or engage in similar quiet and sitting activities.
Experimental: Daytime Sleep - Nap
The participants will be asked to try and take a 30-minute nap. The participant will be provided with a bed in a dark and quiet room.
Related Therapeutic Areas
Sponsors
Collaborators: University of Copenhagen
Leads: Zealand University Hospital

This content was sourced from clinicaltrials.gov