Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to find out whether levothyroxine reduces complications and improves the prognosis of patients with subclinical hypothyroidism (SCH) undergoing coronary artery bypass grafting (CABG). The main questions this study aims to answer are: • Does levothyroxine reduce major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and new arrhythmias, in SCH patients undergoing CABG? Researchers will compare patients who take levothyroxine with those who do not. Participants will: * Be randomly assigned to either receive levothyroxine or not * Start the medication one day before surgery if assigned to the treatment group. * Have regular follow-up visits to check thyroid function and cardiovascular events for up to five years after surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Maximum Age: 90
Healthy Volunteers: f
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⁃ Eligibility Criteria

• Adults aged 19 to 90 years.

• Patients scheduled to undergo coronary artery bypass graft (CABG) surgery.

• Subclinical hypothyroidism (SCH), defined as a normal free thyroxine (free T4) level and a thyroid-stimulating hormone (TSH) level greater than 4 μIU/mL, based on testing performed within 31 days prior to surgery.

Locations
Other Locations
Republic of Korea
Department of Internal Medicine, Seoul National University Bundang Hospital
RECRUITING
Seongnam-si
Contact Information
Primary
Min Joo Kim, Professor
chorong24@gmail.com
+82-31-787-7855
Time Frame
Start Date: 2022-02-27
Estimated Completion Date: 2037-02-26
Participants
Target number of participants: 338
Treatments
Experimental: LT4 group
Participants in this group will receive levothyroxine
No_intervention: Control group
Participants in this group will not receive levothyroxine
Sponsors
Leads: Seoul National University Bundang Hospital

This content was sourced from clinicaltrials.gov

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