Long-term Prognosis of Korean Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy(CADASIL) Patients: A Multicenter Prospective Study
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia. The investigators will track symptoms, brain scans, memory tests, and gene information to understand disease progression in Koreans and identify better treatments. Participants will visit clinics regularly for check-ups and blood tests. This study aims to help improve care for CADASIL patients and families worldwide.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Healthy Volunteers: f
View:
• Age ≥ 19 years
• CADASIL suspected or confirmed by genetic testing (NOTCH3 mutation)
• Able to provide written informed consent (participant or legally authorized representative)
Locations
Other Locations
Republic of Korea
Jeju National University Hospital
RECRUITING
Jeju City
Contact Information
Primary
Jay Chol Professor Choi, MD, PhD, MD, PhD
jaychoi@jejunu.ac.kr
+82-64-754-8160
Time Frame
Start Date: 2023-07-10
Estimated Completion Date: 2040-12-31
Participants
Target number of participants: 500
Treatments
Korean CADASIL Cohort
Genetically confirmed NOTCH3 mutation carriers followed prospectively for 10 years with regular clinical evaluations, neuroimaging, neuropsychological assessments, and laboratory testing. No investigational interventions administered.
Related Therapeutic Areas
Sponsors
Collaborators: Seoul National University Bundang Hospital, Seoul National University Hospital, Yeungnam University Hospital, Asan Medical Center, Chonnam National University Hospital, Kyung Hee University Hospital, Chungbuk National University Hospital, Jeonbuk National University Hospital, Korea University Guro Hospital, Daejeon Eulji Medical Center, Ulsan University Hospital, Hallym University Medical Center, Keimyung University Dongsan Medical Center, Kangdong Sacred Heart Hospital, Dong-A University Hospital, Korea University Ansan Hospital, Ewha Woman University Medical Center, Nowon Eulji Medical Center, Severance Hospital, Seoul Medical Center, Pusan National University Hospital, Soonchunhyang University Hospital, Hanyang University Seoul Hospital, Inje University Ilsan Paik Hospital, Kyungpook National University Hospital
Leads: Jeju National University Hospital