Sleep for Stroke Management and Recovery Trial
Status: Recruiting
Location: See all (116) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Ischemic stroke within the prior 7 days.
• NIH Stroke Scale Score ≥1 at the time of enrollment
⁃ 1\. Ischemic stroke or TIA with ABCD ≥4, within prior 14 days.
Locations
United States
Alabama
University of Alabama Hospital
RECRUITING
Birmingham
Arizona
Chandler Regional Medical Center
TERMINATED
Chandler
Banner University Medical Center Phoenix
RECRUITING
Phoenix
Dignity Health - St. Joseph's Hospital and Medical Center
RECRUITING
Phoenix
Banner- University Medical Center Tucson
RECRUITING
Tucson
TMC Healthcare
TERMINATED
Tucson
California
Mercy San Juan Medical Center
TERMINATED
Carmichael
Rancho Los Amigos National Rehabilitation Center
TERMINATED
Downey
Scripps Memorial
RECRUITING
La Jolla
UCSD Health La Jolla
RECRUITING
La Jolla
Cedars-Sinai Medical Center
RECRUITING
Los Angeles
Kaiser Permanente Los Angeles
RECRUITING
Los Angeles
Ronald Reagan UCLA Medical Center
RECRUITING
Los Angeles
Doctors Medical Center of Modesto
RECRUITING
Modesto
UCLA Kaiser Fontana
RECRUITING
Ontario
UC Irvine
RECRUITING
Orange
Casa Colina
RECRUITING
Pomona
Kaiser Redwood
RECRUITING
Redwood City
UC Davis Medical Center
RECRUITING
Sacramento
UCSD Medical Center - Hillcrest Hospital
RECRUITING
San Diego
UCSF Helen Diller Medical Center at Parnassus Heights
RECRUITING
San Francisco
Orange County Global Medical Center
RECRUITING
Santa Ana
Olive View- UCLA Medical Center
TERMINATED
Sylmar
John Muir Medical Center- Walnut Creek Campus
TERMINATED
Walnut Creek
Colorado
St. Mary's Hospital and Medical Center
RECRUITING
Grand Junction
Connecticut
Hartford Hospital
RECRUITING
Hartford
Yale-New Haven Hospital
RECRUITING
New Haven
Washington, D.c.
George Washington University Hospital
TERMINATED
Washington D.c.
Florida
Morton Plant Hospital
RECRUITING
Clearwater
Broward Health
RECRUITING
Fort Lauderdale
UF Health Shands Hospital
TERMINATED
Gainesville
Brooks Rehabilitation Hospital
RECRUITING
Jacksonville
UF Jacksonville
RECRUITING
Jacksonville
Baptist Hospital of Miami
TERMINATED
Miami
Jackson Memorial Hospital
RECRUITING
Miami
Sarasota Memorial Hospital
RECRUITING
Sarasota
St. Joseph's Hospital
RECRUITING
Tampa
Tampa General Hospital
TERMINATED
Tampa
Georgia
Grady Memorial Hospital
RECRUITING
Atlanta
Iowa
Iowa Methodist
RECRUITING
Des Moines
University of Iowa Hospitals and Clinics
RECRUITING
Iowa City
Illinois
Rush University Medical Center
RECRUITING
Chicago
University of Chicago
RECRUITING
Chicago
University of Illinois Hospital and Health Sciences System
RECRUITING
Chicago
OSF Saint Francis Medical Center
TERMINATED
Peoria
Memorial Medical Center
TERMINATED
Springfield
Kentucky
Norton HealthCare
RECRUITING
Louisville
Louisiana
Ochsner Medical Center - Main Campus
TERMINATED
New Orleans
University Health Shreveport
RECRUITING
Shreveport
Massachusetts
Beth Israel Deaconess Medical Center
RECRUITING
Boston
Massachusetts General Hospital
TERMINATED
Boston
Tufts Medical Center
TERMINATED
Boston
UMass Memorial Medical Center,
RECRUITING
Worcester
Maryland
University of Maryland
RECRUITING
Baltimore
Michigan
Henry Ford Hospital
RECRUITING
Detroit
McLaren Flint
RECRUITING
Flint
Trinity Health Saint Mary's
RECRUITING
Grand Rapids
Bronson Methodist Hospital
RECRUITING
Kalamazoo
Minnesota
Mayo Clinic Saint Marys Campus
RECRUITING
Rochester
Saint Cloud/Centracare Health
RECRUITING
Saint Cloud
Missouri
Saint Luke's Hospital of Kansas City
RECRUITING
Kansas City
Cox Medical Center
RECRUITING
Springfield
Barnes-Jewish Hospital
RECRUITING
St Louis
Mississippi
University of Mississippi Medical Center
RECRUITING
Jackson
North Carolina
Carolinas Medical Center Atrium Health
RECRUITING
Charlotte
Carolinas Rehab Northeast
RECRUITING
Concord
Guilford Neurologic Associates, Inc
RECRUITING
Greensboro
Wake Forest University Baptist Medical Center
RECRUITING
Winston-salem
Nebraska
University of Nebraska Medical Center
TERMINATED
Omaha
New Jersey
JFK Neuroscience Institute
RECRUITING
Edison
Cooperman Barnabas Medical Center
RECRUITING
Livingston
Hackensack Meridian Jersey Shore University Medical Center
RECRUITING
Neptune City
New Mexico
University of New Mexico Hospital
RECRUITING
Albuquerque
New York
Maimonides Medical Center
RECRUITING
Brooklyn
NYU Langone Brooklyn
RECRUITING
Brooklyn
Buffalo General Medical Center
RECRUITING
Buffalo
North Shore University Hospital
RECRUITING
Manhasset
Bellevue Hospital
RECRUITING
New York
NYP Columbia University Medical Center
RECRUITING
New York
NYU Langone -Tish Hospital Medical Center
RECRUITING
New York
Strong Memorial Hospital
ACTIVE_NOT_RECRUITING
Rochester
Staten Island University Hospital
TERMINATED
Staten Island
Suny Upstate Medical University
RECRUITING
Syracuse
Montefiore Medical Center
TERMINATED
The Bronx
Ohio
Christ Hospital
RECRUITING
Cincinnati
University of Cincinnati Medical Center
RECRUITING
Cincinnati
Cleveland Clinic
TERMINATED
Cleveland
UH Cleveland Medical Center
RECRUITING
Cleveland
OSU Wexner Medical Center
RECRUITING
Columbus
West Chester Hospital
RECRUITING
West Chester
Oklahoma
St. John Health System
RECRUITING
Tulsa
Oregon
Providence St. Vincent Medical Center
RECRUITING
Portland
Pennsylvania
St. Luke's University Hospital Bethlehem Campus
TERMINATED
Bethlehem
Geisinger Clinic
TERMINATED
Danville
Penn State Milton S. Hershey Center
RECRUITING
Hershey
Hospital of the University of Pennsylvania
RECRUITING
Philadelphia
Temple University Hospital
RECRUITING
Philadelphia
UPMC Presbyterian Hospital
RECRUITING
Pittsburgh
South Carolina
Palmetto Health Richland
RECRUITING
Columbia
Greenville Memorial Hospital
RECRUITING
Greenville
South Dakota
Avera Research Institute
RECRUITING
Sioux Falls
Tennessee
Fort Sanders Regional Medical Center
RECRUITING
Knoxville
Methodist University
RECRUITING
Memphis
Texas
Baylor Scott & White Institute of Rehabilitation
TERMINATED
Dallas
Memorial Hermann Texas Medical Center
RECRUITING
Houston
Utah
Intermountain Medical Center
RECRUITING
Murray
University of Utah Healthcare
RECRUITING
Salt Lake City
Virginia
UVA Medical Center
RECRUITING
Charlottesville
Inova Fairfax
TERMINATED
Falls Church
Virginia Commonwealth University
RECRUITING
Richmond
Vermont
The University of Vermont Medical Center Main Campus
TERMINATED
Burlington
Washington
Harborview Medical Center
RECRUITING
Seattle
Virginia Mason Medical Center
TERMINATED
Seattle
Wisconsin
Gundersen Lutheran Medical Foundation
TERMINATED
La Crosse
University of Wisconsin University Hospital
RECRUITING
Madison
West Virginia
Ruby Memorial Hospital
RECRUITING
Morgantown
Contact Information
Primary
Kayla Novitski, MPH, CCRP
kcgossel@med.umich.edu
Backup
Joelle Sickler, MSN, CCRC, CCRA
sicklejb@ucmail.uc.edu
Time Frame
Start Date: 2019-05-09
Estimated Completion Date: 2026-11
Participants
Target number of participants: 3062
Treatments
Experimental: Intervention Arm: CPAP with Usual Care.
6 months of CPAP plus usual medical therapy.
No_intervention: Control Arm: Usual Care.
6 months of usual medical therapy alone.
Authors
Rob Buechler, Haitham Hussein, Arbi Ohanian, Hormozd Bozorgchami, Dani Choufani, Christine Holmstedt, Thomas Rogers, Cintasha Redmond, Mohammad Moussavi, James Mojica, Franklin Marden, Clemens Schirmer, Elisheva Coleman, Lucian Maidan, Oana Dumitrascu, Hesham Allam, Gottfried Schlaug, David Wang, William Scott Burgin, Michael Schneck, Suzanne Crandall, Eric Geiser, Nabil Wees, Justin Malone, Mouhammad Jumaa, Roople Unia, Deviyani Mehta, Laura Bishop, Steven Rudolph, Kathleen Burger, sanskriti Mishra, Pierre Fayad, Soo Young Kwon, Mehari Gebreyohanns, Dimitrios Giannakidis, Arun Talkad, Muna Irfan, Sudha Tallavajhula, Elizabeth Hartman, Sami Al Kasab, Paul Katz, Dennis Dietrich, Fatima Milfred, Joanna Ramiro, Curtis Benesch, Ken Uchino, Mark Domroese, Prabhu Emmady, Jaime Boero, Jose Rafael Romero, Gautam Sachdeva, Shyam Prabhakaran, David Salvatore, Stuart Glassner, Syeda Imama Naqvi, Neal Rao, Brynn Dredla, Dennis Auckley, Jeffrey Saver, Ajay Tunguturi, Fazeel Siddiqui, Saqib Chaudhry, Dan Joseph Capampangan, Hrayr Pierre Attarian, Sanjeev Sivakumar, David Teeple, Joseph Hanna, Osama Zaidat, Hermann Christian Schumacher, Bilal Butt, Laurence Krain, Zeshaun Khawaja, Vivien Lee, Christopher Commichau, Dan Gzesh, Ganesh Asaithambi, Mark Goetting, Kumar Rajamani, Milena Pavlova, Koto Ishida, Nicholas Osteraas, Gillian Gordon-Perue, Michel Torbey, Richard Zweifler, Joni Clark, Megan Donohue, Armand Wolff, Sasikanth Gorantla, Marc Lazzaro, Sandeep Kumar
Related Therapeutic Areas
Sponsors
Collaborators: FusionHealth LLC, Medical University of South Carolina, University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS)
Leads: University of Michigan