Cyclic Neutropenia Overview
Learn About Cyclic Neutropenia
Cyclic neutropenia is a disorder that causes frequent infections and other health problems in affected individuals. People with this condition have recurrent episodes of neutropenia during which there is a shortage (deficiency) of neutrophils. Neutrophils are a type of white blood cell that plays a role in inflammation and in fighting infection. The episodes of neutropenia are apparent at birth or soon afterward. For most affected individuals, neutropenia recurs every 21 days and lasts about 3 to 5 days.
Mutations in the ELANE gene cause cyclic neutropenia. The ELANE gene provides instructions for making a protein called neutrophil elastase, which is found in neutrophils. When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase. This protein then modifies the function of certain cells and proteins to help fight the infection.
Cyclic neutropenia is a rare condition and is estimated to occur in 1 in 1 million individuals worldwide.
Cyclic neutropenia is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
David Dale is a primary care provider, practicing in Internal Medicine in Seattle, Washington. Dr. Dale is rated as an Elite provider by MediFind in the treatment of Cyclic Neutropenia. His top areas of expertise are Agranulocytosis, Chronic Familial Neutropenia, Cyclic Neutropenia, and Infantile Neutropenia. Dr. Dale is currently accepting new patients.
Karl Welte practices in Hannover, Germany. Mr. Welte is rated as an Elite expert by MediFind in the treatment of Cyclic Neutropenia. His top areas of expertise are Agranulocytosis, Cyclic Neutropenia, Severe Congenital Neutropenia, Chronic Familial Neutropenia, and Bone Marrow Transplant.
Maksim Klimiankou practices in Tuebingen, Germany. Mr. Klimiankou is rated as an Elite expert by MediFind in the treatment of Cyclic Neutropenia. His top areas of expertise are Agranulocytosis, Cyclic Neutropenia, Severe Congenital Neutropenia, and Chronic Familial Neutropenia.
Summary: The objective of the Serial Blood Count Study is to determine the utility of home monitoring of white blood cell (WBC) and absolute neutrophil counts (ANC) to diagnose cyclic neutropenia and distinguish between cyclic and severe congenital neutropenia (SCN). A new home monitoring device called Athelas One was granted an FDA 510K Class 2 clearance for evaluation of white blood count (WBC) and absol...
Published Date: October 01, 2018
Published By: National Institutes of Health