Learn About Cytomegalic Inclusion Disease

What is the definition of Cytomegalic Inclusion Disease?
Cytomegalic inclusion disease is an infection in newborns caused by the cytomegalovirus. When a pregnant woman has an active cytomegalovirus infection during pregnancy or breastfeeding, the virus can be passed to their babies. Cytomegaloviruses are also known as salivary gland viruses.
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What are the symptoms of Cytomegalic Inclusion Disease?
Symptoms of cytomegalic inclusion disease in the newborn can range from no symptoms to severe symptoms affecting the central nervous system, liver, spleen, and possibly causing developmental disabilities. Other symptoms of severe cytomegalic inclusion disease in infants may include hemorrhagic anemia, low birth weight, fever, hepatitis, yellowing of the skin and whites of the eyes, rash, purple skin blotches, pneumonia, enlarged liver and/or spleen, decreased blood platelets, eye inflammation, abnormally small head, calcification of the ventricles of the brain, developmental motor defects, cognitive disabilities, spastic paralysis, blindness, deafness, and seizures.
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What are the current treatments for Cytomegalic Inclusion Disease?
There is currently no cure for cytomegalic inclusion disease. Treatment for cytomegalic inclusion disease is focused on controlling symptoms. Treatments for cytomegalic inclusion disease include antiviral drugs, such as gancicolovir and foscarnet; azathioprine; prednisone; basiliximab; and miconazole.
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What are the latest Cytomegalic Inclusion Disease Clinical Trials?
A Phase 1/2 Clinical Study to Evaluate the Optimal Dose and the Protective Effect of CMV-MVA Triplex Vaccine in Pediatric Patients Receiving an Allogeneic Hematopoietic Stem Cell Transplant

Summary: This phase I/II trial studies the side effects and best dose of multi-antigen cytomegalovirus (CMV)-modified vaccinia ankara vaccine and to see how well it works in treating pediatric patients with positive cytomegalovirus who are undergoing donor stem cell transplant. Multi-antigen CMV-modified vaccinia ankara vaccine may help people resist CMV life-threatening complications.

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A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus Vaccine mRNA-1647 in Healthy Adults

Summary: This clinical study will assess the safety and immunogenicity of 3 dose levels of mRNA-1647 cytomegalovirus vaccine in CMV-seronegative and CMV-seropositive healthy adults 18-40 years of age.

What are the Latest Advances for Cytomegalic Inclusion Disease?
Effect of sorafenib maintenance on Epstein-Barr virus and cytomegalovirus infections in patients with FLT3-ITD AML undergoing allogeneic hematopoietic stem cell transplantation: a secondary analysis of a randomized clinical trial.
Recurrent Cytomegalovirus Infection Controlled by the Introduction of Everolimus in a Simultaneous Pancreas-Kidney Transplantation Recipient: A Case Report.
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Oral valganciclovir in human immunodeficiency virus-positive patients suffering from cytomegalovirus retinitis at a tertiary care hospital in North India.