What is the definition of Cytomegalovirus Infection?

Cytomegalovirus (CMV) infection is a disease caused by a type of herpes virus.

What are the alternative names for Cytomegalovirus Infection?

CMV mononucleosis; Cytomegalovirus; CMV; Human cytomegalovirus; HCMV

What are the causes for Cytomegalovirus Infection?

Infection with CMV is very common. The infection is spread by:

  • Blood transfusions
  • Organ transplants
  • Respiratory droplets
  • Saliva
  • Sexual contact
  • Urine
  • Tears

Most people come into contact with CMV in their lifetime. But usually, it's people with a weakened immune system, such as those with HIV/AIDS, who become ill from CMV infection. Some otherwise healthy people with CMV infection develop a mononucleosis-like syndrome.

CMV is a type of herpes virus. All herpes viruses remain in your body for the rest of your life after infection. If your immune system becomes weakened in the future, this virus may have the chance to reactivate, causing symptoms.

What are the symptoms for Cytomegalovirus Infection?

Many people are exposed to CMV early in life, but do not realize it because they have no symptoms, or they have mild symptoms that resemble the common cold. These may include:

  • Enlarged lymph nodes, especially in the neck
  • Fever
  • Fatigue
  • Loss of appetite
  • Malaise
  • Muscle aches
  • Rash
  • Sore throat

CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected. Examples of body areas that can be infected by CMV are:

  • The lungs
  • The stomach or intestine
  • The back of the eye (retina)
  • A baby while still in the womb (congenital CMV)

What are the current treatments for Cytomegalovirus Infection?

Most people recover in 4 to 6 weeks without medicine. Rest is needed, sometimes for a month or longer to regain full activity levels. Painkillers and warm salt-water gargles can help relieve symptoms.

Antiviral medicines are usually not used in people with healthy immune function, but may be used for people with an impaired immune system.

What is the outlook (prognosis) for Cytomegalovirus Infection?

Outcome is good with treatment. The symptoms may be relieved in a few weeks to months.

What are the possible complications for Cytomegalovirus Infection?

Throat infection is the most common complication. Rare complications include:

  • Colitis
  • Guillain-Barré syndrome
  • Nervous system (neurologic) complications
  • Pericarditis or myocarditis
  • Pneumonia
  • Rupture of the spleen
  • Inflammation of liver (hepatitis)

When should I contact a medical professional for Cytomegalovirus Infection?

Call for an appointment with your provider if you have symptoms of CMV infection.

Go to the emergency room or call 911 or the local emergency number if you have sharp, severe sudden pain in your left upper abdomen. This could be a sign of a ruptured spleen, which may require emergency surgery.

How do I prevent Cytomegalovirus Infection?

CMV infection can be contagious if the infected person comes in close or intimate contact with another person. You should avoid kissing and sexual contact with an infected person.

The virus may also spread among young children in day care settings.

When planning blood transfusions or organ transplants, the CMV status of the donor can be checked to avoid passing CMV to a recipient who has not had CMV infection.



Britt WJ. Cytomegalovirus.In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 137.

Centers for Disease Control and Prevention website. Cytomegalovirus (CMV) and congenital CMV infection: clinical overview. www.cdc.gov/cmv/clinical/overview.html. Updated August 18, 2020. Accessed December 1, 2020.

Drew WL, Boivin G. Cytomegalovirus. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 352.

  • Journal: BMJ case reports
  • Published —
Cytomegalovirus skin disease in a kidney transplant patient.
  • Condition: Chronic Cytomegalovirus Necrotizing Retinitis in Patient with Scleroderma and Mixed Connective Tissue Disease
  • Journal: Archivos de la Sociedad Espanola de Oftalmologia
  • Treatment Used: Pars Plana Vitrectomy, Intravenous and Intravitreal Ganciclovir
  • Number of Patients: 1
  • Published —
This case report describes a 52-year-old woman with scleroderma, mixed connective tissue disease, and interstitial lung disease, who developed chronic cytomegalovirus necrotizing retinitis treated with pars plana vitrectomy, and intravenous and intravitreal ganciclovir.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 4
  • Intervention Type: Other, Drug
  • Participants: 46
  • Start Date: September 2021
Effect of the Introduction of mTor Inhibitors in the Activation of the Cytomegalovirus (CMV) -Specific Cellular Immune Response to Control Viral Replication in Kidney Transplant Patients
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 4
  • Intervention Type: Drug
  • Participants: 35
  • Start Date: July 1, 2021
Evaluation of the Tolerability and Clinical Effectiveness of Letermovir in Heart Transplantation