What is the definition of D-Minus Hemolytic Uremic Syndrome?

D-minus (diarrhea negative) hemolytic uremic syndrome is an extremely rare, progressive genetic disease characterized by low levels of red blood cells (hemolytic anemia), low platelets (thrombocytopenia), and an inability of the kidneys to process waste products from the blood (uremia).

What are the symptoms for D-Minus Hemolytic Uremic Syndrome?

Symptoms of D-minus hemolytic uremic syndrome may include malaise, fatigue, irritability, lethargy, decreased urine, paleness, scattered bruising, gastrointestinal bleeding, high blood pressure, headaches, double vision, facial paralysis, stroke, seizures, coma, fluid in the lungs, enlarged heart, and kidney failure.

What are the current treatments for D-Minus Hemolytic Uremic Syndrome?

Treatment for D-minus hemolytic uremic syndrome may include intravenous nutrition and fluid replacement, kidney or peritoneal dialysis, blood transfusion, vasodilators, medications, such as eculizumab and ultomiris (favulizumab-cwyz), plasma exchange (plasmapheresis), immunosuppressive therapy, or kidney transplant.
  • Condition: Atypical Hemolytic Uremic Syndrome (aHUS)
  • Journal: The American journal of case reports
  • Treatment Used: Hemodialysis, Corticosteroids, Plasma Exchange, and Eculizumab
  • Number of Patients: 1
  • Published —
This case report describes a 58-year-old man diagnosed with atypical hemolytic uremic syndrome (aHUS) treated with hemodialysis, corticosteroids, plasma exchange, and eculizumab.
  • Condition: Urate Nephropathy from Tumor Lysis Syndrome (TLS) in an Undiagnosed Case of Prostate Cancer
  • Journal: Current oncology (Toronto, Ont.)
  • Treatment Used: Urgent Hemodialysis
  • Number of Patients: 1
  • Published —
This case report describes a patient with metastatic prostate cancer which remained undiagnosed until the patient developed tumor lysis syndrome (TLS), leading to urate nephropathy treated with urgent hemodialysis.