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Learn About D-Plus Hemolytic Uremic Syndrome

What is the definition of D-Plus Hemolytic Uremic Syndrome?
D-plus (diarrhea positive) hemolytic uremic syndrome, also known as STEC hemolytic uremic syndrome, is a rare disease that affects children between one and ten years old which is characterized by low levels of red blood cells (hemolytic anemia), low platelets (thrombocytopenia), and an inability of the kidneys to process waste products from the blood (uremia). D-plus hemolytic uremic syndrome develops after certain bacterial infections, such as Escherichia. coli (E. coli) that cause diarrhea.
What are the symptoms of D-Plus Hemolytic Uremic Syndrome?
Symptoms of D-plus hemolytic uremic syndrome can be mild or severe and usually appear after an illness that is characterized by fever, abdominal cramps and pain, nausea, vomiting, and bloody diarrhea (gastroenteritis). Symptoms of D-plus hemolytic uremic syndrome may include paleness, irritability, weakness, reduced urinary output or no urine, lethargy, acute kidney injury, chronic kidney disease, protein in the urine, unexplained bruising, nosebleeds, high blood pressure, gallstones, neurological deficits, confusion, partial paralysis, seizures, coma, pancreatitis, and diabetes mellitus.
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What are the current treatments for D-Plus Hemolytic Uremic Syndrome?
Treatment for D-minus hemolytic uremic syndrome may include intravenous fluid and nutrition replacement, kidney or peritoneal dialysis, blood transfusion, vasodilators, medications, such as eculizumab and ultomiris (favulizumab-cwyz), plasma exchange (plasmapheresis), immunosuppressive therapy, or kidney transplantation.
Who are the top D-Plus Hemolytic Uremic Syndrome Local Doctors?
Robert A. Brodsky
Elite in D-Plus Hemolytic Uremic Syndrome
Pathology | Hematology | Oncology
Elite in D-Plus Hemolytic Uremic Syndrome
Pathology | Hematology | Oncology

Sidney Kimmel Comprehensive Cancer Center

401 North Broadway Street, Weinberg BLDG, Weinberg BLDG, 
Baltimore, MD 
Languages Spoken:
English

Dr. Robert Brodsky is a professor of medicine at the Johns Hopkins University School of Medicine. His area of clinical expertise is classical hematology and haploidentical bone marrow transplant for sickle cell disease and aplastic anemia. Dr. Brodsky serves as the director of the Division of Hematology and the T32 Training Program. He is the Johns Hopkins Family Professor of Medicine and Oncology. He received his M.D. from Hahnemann University. He completed his residency at the Vanderbilt University School of Medicine. He performed a fellowship in hematology at the National Institutes of Health and a fellowship in oncology at Johns Hopkins. He joined the Johns Hopkins faculty in 1997. From 2017 to 2022 he served as Associate Editor to The Journal of Clinical Investigation (JCI) and Secretary to American Society of Hematology (ASH). He serves as President of The American Society of Hematology (ASH) in 2023. Dr. Brodsky is rated as an Elite provider by MediFind in the treatment of D-Plus Hemolytic Uremic Syndrome. His top areas of expertise are Paroxysmal Nocturnal Hemoglobinuria (PNH), Paroxysmal Cold Hemoglobinuria, Anemia, Bone Marrow Transplant, and Splenectomy.

Christophe M. Legendre
Elite in D-Plus Hemolytic Uremic Syndrome
Elite in D-Plus Hemolytic Uremic Syndrome
Paris, FR 

Christophe Legendre practices in Paris, France. Mr. Legendre is rated as an Elite expert by MediFind in the treatment of D-Plus Hemolytic Uremic Syndrome. His top areas of expertise are D-Plus Hemolytic Uremic Syndrome, Hemolytic-Uremic Syndrome, D-Minus Hemolytic Uremic Syndrome, Kidney Transplant, and Nephrectomy.

 
 
 
 
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Elite in D-Plus Hemolytic Uremic Syndrome
Elite in D-Plus Hemolytic Uremic Syndrome
Via Della Commenda 9, 
Milan, IT 

Gianluigi Ardissino practices in Milan, Italy. Mr. Ardissino is rated as an Elite expert by MediFind in the treatment of D-Plus Hemolytic Uremic Syndrome. His top areas of expertise are Hemolytic-Uremic Syndrome, D-Minus Hemolytic Uremic Syndrome, D-Plus Hemolytic Uremic Syndrome, Atypical Hemolytic Uremic Syndrome (aHUS), and Kidney Transplant.

What are the latest D-Plus Hemolytic Uremic Syndrome Clinical Trials?
The Burden of Atypical Hemolytic Uremic Syndrome and The Clinical Characteristics of Patients in Egyptian Hospitals A Multicenter, Observational, Retrospective Cohort Study in Egypt

Summary: Atypical hemolytic uremic syndrome (aHUS) is a rare, progressive, and life-threatening disease that occurs at any age, with incidence rate of 0.75 to 2.0 cases per million population per year. aHUS is a thrombotic microangiopathy (TMA) commonly caused by dysregulation of the complement system, affecting several organs, especially the kidneys. aHUS can be familial or sporadic, and approximately 50%...

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A Phase III Study to Evaluate the Efficacy of INM004 (Shiga Antitoxin) in Pediatric Patients With Shiga Toxin-producing Escherichia Coli-associated Hemolytic Uremic Syndrome.

Summary: The objectives of this study are to evaluate the efficacy, safety, and pharmacokinetics of INM004 in pediatric patients with Hemolytic Uremic Syndrome associated to infection by Shiga toxin-producing Escherichia coli (STEC-HUS).