Comparative Study Between Demineralized and Mineralized Allogeneic Dentin Grafts for Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.
• Adults aged 18 to 60 years.
• Medically healthy patients classified as ASA I.
• Presence of a single non-restorable tooth indicated for extraction in the posterior maxilla.
• Adequate oral hygiene, with plaque and bleeding indices both below 20%.
• Sufficient bone volume to allow socket preservation without requiring simultaneous augmentation.
• Patients willing to participate in the study and able to provide written informed consent.
• Ability to commit to follow-up visits for up to 6 months.