Impact of Intraoperative Hemodynamic Instability on Postoperative Major Adverse Events in Cardiac Surgery Patients: A Prospective Cohort Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear. This prospective cohort study aims to evaluate the association between intraoperative hemodynamic instability (defined as MAP \< 65 mmHg or vasopressor requirement) and major postoperative complications (Delirium, Acute Kidney Injury, Stroke, or Mortality) in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients aged 18 years or older.

• Scheduled for elective cardiac surgery (CABG, Valve replacement/repair, or combined procedures).

• Surgery performed under cardiopulmonary bypass (CPB).

• Preoperative sinus rhythm.

• Signed informed consent form.

Locations
Other Locations
Turkey
Gazi Yaşargil Training and Research Hospital
RECRUITING
Diyarbakır
Contact Information
Primary
Osman Uzundere, M.D.
osmanuzundere@gmail.com
+905330206362
Time Frame
Start Date: 2025-04-26
Estimated Completion Date: 2026-02-05
Participants
Target number of participants: 230
Treatments
Hemodynamic Instability Group
Patients who exhibit intraoperative hemodynamic instability, defined as Mean Arterial Pressure (MAP) \< 65 mmHg for \>5 minutes continuously, or requiring vasopressor/inotropic support to maintain MAP.
Hemodynamically Stable Group
Patients who maintain intraoperative hemodynamic stability without significant hypotension episodes (MAP \> 65 mmHg) or vasopressor requirement beyond baseline anesthesia induction.
Related Therapeutic Areas
Sponsors
Leads: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

This content was sourced from clinicaltrials.gov