Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:

• English Speaking

• Willing to provide consent

Locations
United States
North Carolina
Duke University Hospital
RECRUITING
Durham
Contact Information
Primary
Simon W Davis, PhD
simon.davis@duke.edu
9196841243
Backup
Emily Finch, BA
emily.finch@duke.edu
9196682842
Time Frame
Start Date: 2024-03-28
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 150
Treatments
Experimental: TMS-Randomized
Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In the first condition, arrhythmic TMS trains with a stochastic (randomized) inter-pulse interval, will be used to disrupt cortical alpha oscillations and thus be expected to enhance memory performance.
Experimental: TMS-Ordered
Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In the second condition, rhythmic (ordered) alpha-frequency TMS trains, with the expectation that this alpha stimulation will further entrain a synchronization during the task and thereby worsen memory performance.
Sham_comparator: TMS-Sham
Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In a third condition, sham stimulation will be delivered at the same randomized inter-pulse interval, but with no TMS delivered to the brain.
Related Therapeutic Areas
Sponsors
Leads: Duke University
Collaborators: National Institute on Aging (NIA)

This content was sourced from clinicaltrials.gov

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