Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. \[exploratory\]

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: t
View:

• Overall cognitive functional status consistent with amnesic MCI (CDR 0.5) likely due to AD (AD biomarker supported)

• 50-80 years of age

• English native speakers

Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Charlestown
Contact Information
Primary
DNN Inbox
mghdnn@mgh.harvard.edu
6177265348
Time Frame
Start Date: 2025-01-31
Estimated Completion Date: 2026-06
Participants
Target number of participants: 70
Treatments
Placebo_comparator: Healthy Controls
Experimental: MCI Subjects
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital

This content was sourced from clinicaltrials.gov