Examining the Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV (HEALTH-Cog)
People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or examined mechanisms of adherence to long-term exercise among diverse samples of midlife and older people with HIV. The current study will leverage an existing R01 to address these gaps and provide implications for development of personalized approaches for the treatment and prevention of cognitive impairment and dementia in older people with HIV.
• Confirmed HIV
• Sedentary lifestyle, defined as self-reported PA that breaks a sweat \<3 days/week, with no regular resistance exercise for 3 months preceding study;
• Fatigued (≥2.0 on either of the first two screening items on the HIV-Related Fatigue Scale)
• On a current, contemporary ART regimen for \>=12 months;
• HIV-1 RNA \<200 copies/mL in the past 12 months (assessed via medical records)
• Willing to engage in a supervised exercise program 3 times/week for 4 months
• Cell phone or email to accept messages
• Weight \<450 lbs
• Medical clearance by study healthcare professional