Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor
Status: Recruiting
Location: See location...
Intervention Type: Other, Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The aim of the study is to investigate the effect of coenzyme Q10 supplementation (150 mg/b.i.d, 300 mg/d, 12 weeks) on coenzyme Q10, glucose parameters, BDNF, myokines, and cognitive function in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients who combined with hyperglycemia but without sarcopenia, or with hyperglycemia and pre-sarcopenia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:
• Clinical diagnosis of mild cognitive impairment (MCI).
• Clinical diagnosis of Alzheimer's Disease.
• MCI and AD patients with hyperglycemia ( Fasting glucose \>=100 mg/dL).
• MCI and AD patients with pre-sarcopenia (low calf circumference, low hand grip, or low muscle endurance).
• Must be able to swallow tablets.
Locations
Other Locations
Taiwan
Chung Shan Medical University Hospital
RECRUITING
Taichung
Contact Information
Primary
Ping-Ting Lin, Ph.D.
apt810@csmu.edu.tw
+886-4-24730022
Time Frame
Start Date: 2023-12-26
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 100
Treatments
Experimental: Coenzyme Q10
Coenzyme Q10 300 mg/day (150 mg/b.i.d.)
Placebo_comparator: Placebo
Placebo (dextrin)
Related Therapeutic Areas
Sponsors
Collaborators: National Science and Technology Council
Leads: Chung Shan Medical University