Cognitive Control Amongst Older Adults with Depressive Symptom: Mechanisms and Intervention

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The prevalence of depressive symptoms in older adults is on the rise, affecting 13 to 37% of older adults globally. These symptoms significantly impact health, increasing the risk of dementia and cognitive decline, and impairing daily functioning and quality of life. Reduced cognitive control (CC) is a key factor contributing to depressive symptoms, affecting 40% of adults with such symptoms. Despite this, over half of affected adults do not respond well to available treatments. Computerized cognitive training (CCT) has shown efficacy in improving CC but its impact on daily functioning is limited. The Cognitive Orientation to Occupational Performance (CO-OP) approach has demonstrated promise in improving daily functioning, as measured by occupational performance (OP). We propose a novel intervention, GOLD-Cog+, combining CCT and CO-OP, to address CC and functional deficits in older adults with depressive symptoms.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: t
View:

• Depressive Symptoms based on Patient Health Questionnaire (PHQ-8) ≥ 5

• Healthy Cognition based on Montreal Cognitive Assessment (MoCa) ≥ 20

• Capable of signing and agreeing to participate in the study

• Have the basic technological skills to use a tablet based on self-report

• Adequate sight and hearing abilities (with assistive technology) to be able to use a tablet and fully participate in a small group setting (6 people)

• Ability to fluently read, speak and understand Hebrew or English

Locations
Other Locations
Israel
Computerized Neurotherapy Lab, School of OT, Hebrew University, Mt. Scopus Campus
RECRUITING
Jerusalem
Contact Information
Primary
Eliane Gefen, MsC
eliane.lavon@mail.huji.ac.il
0548075722
Backup
Mor Nahum, Professor
mor.nahum@mail.huji.ac.il
Time Frame
Start Date: 2024-02-02
Estimated Completion Date: 2025-09
Participants
Target number of participants: 42
Treatments
Experimental: GOLD-Cog+
The experimental group receives 6 weeks of combined cognitive intervention (GOLD-Cog+),which includes participation in 9, one hour long Cognitive-Orientation to Occupational Performance(CO-OP)-based group sessions and 24 individual and independent 30-minute computerized cognitive training (CCT) program using the Effectivate platform (Israeli-based CCT developed for older adults. Available in both Hebrew and English).
No_intervention: Waiting period
The same participants will also participate in 6-weeks of no intervention before or after the 6-week experimental period (i.e. crossover study). This will be used as the 'control' group.
Related Therapeutic Areas
Sponsors
Leads: Hebrew University of Jerusalem
Collaborators: University of Melbourne

This content was sourced from clinicaltrials.gov