Induction and Stabilization of Gamma Oscillations With 40 Hz Transcranial Alternating Current Stimulation in Healthy Elderly
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's disease. Specifically, it examines the effects of 40 Hz tACS applied to frontal brain regions versus fronto-temporal regions on gamma oscillations and working memory in healthy elderly individuals.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 85
Healthy Volunteers: t
View:
• healthy elderly between 50-80 years of age
• normal or corrected to normal eye vision
• right-handed
• non-smokers
• at least 70 % accuracy in working memory training task
Locations
Other Locations
Islamic Republic of Iran
Institute for Research in Fundamental Sciences
RECRUITING
Tehran
Contact Information
Primary
Mohammad Ali Salehinejad, PhD
salehinejad@ifado.de
017642062686
Time Frame
Start Date: 2024-06-01
Estimated Completion Date: 2025-06-01
Participants
Target number of participants: 30
Treatments
Active_comparator: 40 Hz prefrontal Transcranial alternating current stimulation
During prefrontal tACS, an alternating electrical current with a 1 milliamp peak-to-peak amplitude will be delivered, featuring a 15-second ramp-up at the start and a 15-second ramp-down at the end. The stimulation duration is 20 minutes and four channels are used for delivering sinusoidal alternating currents to the head. The alternating current was delivered to the prefrontal cortex bilaterally with the electrodes at F3 and F4 and the return electrodes were placed at the ipsilateral mastoids at TP9 and TP10 (international 10-20 EEG electrode placement system).
Active_comparator: 40 Hz frontal-temporal Transcranial alternating current stimulation
During frontal-temporal tACS, an alternating electrical current with a personalized peak-to-peak stimulation intensity will be delivered, featuring a 15-second ramp-up at the start and a 15-second ramp-down at the end. The stimulation duration is 20 minutes and four channels are used for delivering sinusoidal alternating currents to the head. The alternating current was delivered to the prefrontal and temporal cortices with the active electrodes at AF3-T7 and the return electrodes over AF4-T8 (according international 10-20 EEG electrode placement system).
Sham_comparator: sham Transcranial alternating current stimulation
During sham tACS, an alternating artificial electrical current will be delivered, only ramping the current for 15 seconds up and 15 seconds down at the beginning and end of the stimulation respectively.
Related Therapeutic Areas
Sponsors
Leads: The National Brain Mapping Laboratory (NBML)
Collaborators: Technical University of Dortmund, Institute for Research in Fundamental Sciences (IPM), Leibniz Research Centre for Working Environment and Human Factors