Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:

• Clinical Dementia Rating 0.5 - 2

• Be a person with or caregiver to a person with a diagnosis of early Alzheimer's Disease, mild dementia, and/or mild cognitive impairment (MCI)

• Able to provide informed consent

• Willing to wear an EEG headset and heart rate monitoring devices

• Willing to possibly have small patches of body / facial hair shaved to accommodate administration of heart rate monitoring devices

• Willing to answer survey questions about topics related to the study

• Willing to be audio / video recorded

Locations
United States
Connecticut
Firehouse 12 Studios
RECRUITING
New Haven
Musical Intervention Studios
NOT_YET_RECRUITING
New Haven
Contact Information
Primary
AZA Allsop, MD, PhD
Aza.allsop@yale.edu
240-422-3289
Backup
AZA Lab
azalab@yale.edu
203-903-2157
Time Frame
Start Date: 2025-01-28
Estimated Completion Date: 2025-08
Participants
Target number of participants: 60
Treatments
Experimental: AD / Dementia / MCI participants and caregivers dyads with music
Each participant will take part in two sessions. Both sessions will last up to 3 hours.~Participants will attend a series of live music performances and pre-recorded control session performances. Physiological and survey data will be collected to assess the impact of live versus pre-recorded music on anxiety, social motivation, parasympathetic activity, and neural synchrony.
Related Therapeutic Areas
Sponsors
Collaborators: Renée Fleming Foundation, Howard University, Yale University School of Medicine, Department of Psychiatry, NeuroArts Blueprint Initiative
Leads: Yale University

This content was sourced from clinicaltrials.gov