Development and Validation of an Innovative Gamma Auditory Stimulation System for Older Adults With Cognitive Decline: A Randomized, Double-blind, Placebo-controlled Study (Study 1)
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:
• Age over 60 years old.
• MMSE≤ 24
• CDR scores of 0.5 and 1
• Voluntary to sign the Informed Consent Form.
Locations
Other Locations
Taiwan
Chang Gung University
RECRUITING
Taoyuan
Contact Information
Primary
Chia-Hsiung Cheng, Ph.D.
ch.cheng@mail.cgu.edu.tw
+886-3-211800
Time Frame
Start Date: 2025-11-14
Estimated Completion Date: 2028-11-01
Participants
Target number of participants: 70
Treatments
Experimental: 40Hz music group
The 40Hz music is combined with 40Hz sound and music.
Sham_comparator: Non-40Hz music group
The non-40Hz music is combined with non-40Hz sound and music.
Related Therapeutic Areas
Sponsors
Leads: Chang Gung Memorial Hospital